Matthew Wade posted the highest individual score in Hurricanes history - 130 from 61 deliveries - to anchor a monster total of 1/217. Wade and fellow opener D'Arcy Short (72 from 55 balls) posted 203 for the first wicket, the second highest opening partnership in BBL history.
The Hurricanes will host the Sydney Thunder or travel to Brisbane to face the Heat in Thursday's Eliminator.
After winning the toss and electing to bat, Wade and Short complemented each other perfectly, with Short's ability to keep the scoreboard ticking over proving the perfect foil for Wade's aggressive strokeplay.
Wade was given a chance on 57, with Strikers outfielder Jon Wells dropping a catch off Billy Stanlake's bowling.
Despite surrendering 217, the Strikers put together 8/207 in reply as Phil Salt top-scored with 66.
Strikers stars Alex Carey and Travis Head kept the pressure on in front of a parochial Adelaide Oval crowd, but Scott Boland and James Faulkner made key breakthroughs as the Strikers lost consistent wickets.
Boland, Clive Rose and Nathan Ellis finished with two wickets apiece, with Ellis' two wickets coming in the 20th over.